Dual hormone-secreting pediatric pituitary adenoma: a case report and surgical management
Armando Romero-Pérez, Ana Domínguez-Merino, Claudia Carrillo González, Luis Angel Haro-Santillan
Abstract
Pituitary adenomas are rare in pediatric populations representing only 2–6% of intracranial neoplasms, yet recent reports suggest an increasing incidence with more aggressive features, larger size, and earlier onset compared to adults. We present the case of a 10-year-old female with dual hypersecretion of growth hormone and prolactin who developed tall stature, galactorrhea, headache, visual disturbances, and neurological deficits. Magnetic resonance imaging revealed a sellar mass measuring 4.36 × 3.5 × 3.3 cm, and immunohistochemistry confirmed positivity for growth hormone and prolactin with a Ki-67 index of 2%. The patient underwent an initial craniofacial transcranial resection, but biochemical and radiological recurrence required a second surgery via endoscopic endonasal approach, achieving near-total removal of the tumor. This case illustrates the clinical complexity of pediatric pituitary adenomas with dual hormonal secretion, emphasizes the importance of multidisciplinary management and long-term follow-up, and highlights the advantages of endoscopic endonasal surgery in achieving superior resection rates and lower recurrence compared to traditional approaches.
Keywords
References
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Submitted date:
03/03/2026
Accepted date:
03/22/2026
Publication date:
04/28/2026
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